PVA polymers are functionalized with thiol-reactive groups, which react at a slower rate with thiol groups of crosslinkers (CD/PEG crosslinkers) to form stable hydrogels. The slow gelation kinetics allows enough time to conveniently manipulate the solution before the onset of homogenous gel formation. The thioglycerol is used to maintain hydrogel strength and also as a control to compare cellular behavior in peptide-modified versus unmodified hydrogels.
Application
SLO-PVA polymer is used with crosslinkers (CD/PEG crosslinkers) to establish stable hydrogels
Features and Benefits
Contains synthetic polymer (PVA) functionalized with thiol reactive groups for slow gelation
Non degradable polymer
Components
TRUEPVAS contains SLO-PVA solution in phosphate buffer, TrueGel3D thioglycerol and water
Caution
Avoid frequent freeze-thaw cycles and store SLO-PVA in small portions
TrueGel3D™ is a synthetic hydrogels platform for 3D cell culture that aim to mimic the natural extracellular environment for more physiological culture conditions
An advanced protocol is available for TrueGel 3D kits for 3D cell culture for peptides concentration or stiffness optimisation
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