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T0175

Sigma-Aldrich

Troponin T from human heart

≥60% (SDS-PAGE), lyophilized powder

Synonym(s):

Tn-T

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About This Item

CAS Number:
150901-75-0
MDL number:
MFCD00213049
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human heart

Quality Level

200

form

lyophilized powder

purified by

affinity chromatography

concentration

≥60% (SDS-PAGE)

technique(s)

ELISA: suitable

solubility

10 mM HCl: 500 μg/mL, clear, colorless

UniProt accession no.

P45379

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TNNT2(7139)

General description

The cardiac troponin T gene (TNNT2) is located on human chromosome 1 and spans around 17kb. It codes for a 288-amino-acid peptide of 36−39kDa.

Application

Troponin T from human heart has been used in competitive enzyme-linked immunosorbent assay (ELISA) for the quantification of troponin T (TnT).

Biochem/physiol Actions

The tropomyosin-binding subunit of troponin. The cardiac troponin T gene (TNNT2) helps to connect the troponin complex to α-tropomyosin, thereby participates in the modulation of contractile function.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A skeletal muscle troponin T specific ELISA based on the use of an antibody against the soluble troponin T (16-31) fragment
Tsitsilonis O E, et al.
Journal of Immunological Methods, 268(2), 141-148 (2002)
Inherited cardiomyopathies
Emery and Rimoin's Principles and Practice of Medical Genetics, 1-38 (2013)
Nikita Sitkov et al.
Micromachines, 12(6) (2021-07-03)
The problems of chronic or noncommunicable diseases (NCD) that now kill around 40 million people each year require multiparametric combinatorial diagnostics for the selection of effective treatment tactics. This could be implemented using the biosensor principle based on peptide aptamers

Articles

Troponin

Troponin together with tropomyosin, regulate the binding of myosin to actin. Troponin is a trimeric protein composed of Troponin subunits I, C and T. Troponin C binds calcium ions, Troponin T binds to tropomyosin and troponin I binds to actin

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