SML3715

SSK1

≥98% (HPLC)

• Synonym(s): (2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-((((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)oxy)methyl)-2-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
• Empirical Formula (Hill Notation): C₃₁H₃₄F₂N₄O₁₈
• CAS Number: 2629250-69-5
• Molecular Weight: 788.61
• MDL number: MFCD34474020
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Galactose-conjugated senolytic prodrug; induces apoptosis in senescence cells through activation of p38 MAPK

SSK1 is a senescence cells specific killing agent that is activated by lysosomal β-galactosidase. SSK1 induces apoptosis in senescence cells through activation of p38 MAPK. Also, it induces mitochondrial DNA damage in senescent cells. In aged mice, SSK1 removes senescence cells in different tissues, attenuated low-grade inflammation and improved physical function.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable