Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML2966

Sigma-Aldrich

Z-RLRGG-AMC Acetate

≥95% (HPLC)

Synonym(s):

N2-[(Phenylmethoxy)carbonyl]-L-arginyl-L-leucyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-glycinamide, Z-Arg-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin, Z-Arg-Leu-Arg-Gly-Gly-AMC

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$196.00

$196.00

PRICE WITHOUT NATIONAL TAXES
Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$196.00

About This Item

Empirical Formula (Hill Notation):
C40H56N12O9 · xC2H4O2
CAS Number:
167698-69-3
Molecular Weight:
848.95 (free base basis)
UNSPSC Code:
12352209
NACRES:
NA.77

$196.00

PRICE WITHOUT NATIONAL TAXES
Check Cart for Availability
Request a Bulk Order

Quality Level

100

Assay

≥95% (HPLC)

form

film or powder

color

white to beige

storage temp.

−20°C

SMILES string

FC(F)(F)C(=O)O.N([C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)NCC(=O)Nc2cc3c(cc2)C(=CC(=O)O3)C)C(=O)OCc1ccccc1

InChI

1S/C40H56N12O9.C2HF3O2/c1-23(2)17-30(51-36(57)29(12-8-16-46-39(43)44)52-40(59)60-22-25-9-5-4-6-10-25)37(58)50-28(11-7-15-45-38(41)42)35(56)48-20-32(53)47-21-33(54)49-26-13-14-27-24(3)18-34(55)61-31(27)19-26;3-2(4,5)1(6)7/h4-6,9-10,13-14,18-19,23,28-30H,7-

InChI key

CMGDVBCGNGERLC-SZOHVZSOSA-N

Biochem/physiol Actions

Z-RLRGG-AMC is a fluorogenic substrate for the MERS-CoV, SARS-CoV, SARS-CoV-2 papain-like protease (PLpros), deubiquitinating enzyme isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases, which consists of the Ub and ISG15 C-terminal sequences. Z-RLRGG-AMC excitation wavelength is 340 nm, and emission wavelength is 460 nm.
fluorogenic substrate for the MERS-CoV, SARS-CoV, SARS-CoV-2 papain-like protease (PLpros), deubiquitinating enzyme isopeptidase T (IPaseT)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000436350
0000436350
0000310304
0000310304
0000162321

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Brendan T Freitas et al.
ACS infectious diseases, 6(8), 2099-2109 (2020-05-20)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The outbreak currently includes over 3.7 million cases and 260,000 fatalities. As a betacoronavirus, SARS-CoV-2 encodes for a
Yahira M Báez-Santos et al.
Journal of virology, 88(21), 12511-12527 (2014-08-22)
The papain-like protease (PLpro) domain from the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) was overexpressed and purified. MERS-CoV PLpro constructs with and without the putative ubiquitin-like (UBL) domain at the N terminus were found to possess protease, deubiquitinating, deISGylating

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service