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SML0574

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YM-298198 hydrochloride

≥98% (HPLC)

Synonym(s):

6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H22N4OS · HCl
CAS Number:
1216398-09-2
Molecular Weight:
378.92
MDL number:
MFCD08703122
UNSPSC Code:
12352200
PubChem Substance ID:
329825561
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C

InChI

1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H

InChI key

WYTJVUVCSUWZTH-UHFFFAOYSA-N

Biochem/physiol Actions

YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Haein Weon et al.
Life sciences, 188, 110-117 (2017-09-09)
Both N-type and P/Q-type voltage-gated Ca (S)-3,5-Dihydroxyphenylglycine (DHPG; 10μM for 5min), the group I mGluR agonist, was used to induce LTP of excitatory postsynaptic currents that were evoked in the Vo neurons by stimulating the trigeminal track. Weak blockade of

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