Anti-Tyrosine Hydroxylase Antibody detects endogenous levels of total Tyrosine Hydroxylase protein.
The TH (tyrosine Hydroxylase) gene codes for a homotetramer that contains catalytic, regulatory, and tetramerization domains in each of its subunit.
Immunogen
The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase.
Immunogen Range: 41-90
Application
Anti-Tyrosine Hydroxylase, N-Terminal antibody produced in rabbit has ben used in immunohistochemistry.
Biochem/physiol Actions
The conversion of l-tyrosine into l-DOPA (L-3,4-dihydroxyphenylalanine) is catalyzed by tyrosine hydroxylase (TH), which is the rate-limiting step in the in the synthesis of catecholamines such as dopamine and also other necessary hormones and neuromodulators. The TH enzyme deficiency results in low levels of dopamine, which is characterised in Parkinson′s disease.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Parkinsonism & related disorders, 23, 86-90 (2016-01-07)
Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. We investigated whether the presence of a common TH polymorphism
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