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SAB4500363

Sigma-Aldrich

Anti-Collagen I α2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

α 2 type i collagen, co1a2, col1a2, collagen, type i

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 129 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P08123

UniProt accession no.

P08123

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL1A2(1278)

Related Categories

General description

Anti-Collagen I α2 Antibody detects endogenous levels of total Collagen I α2 protein.
Collagen I α2 (COL1A2) is located on human chromosome 7q22.1. Human COL1A2 gene consists of two dinucleotide repeats: one in the 5′-flanking region of the gene, made of of poly(dC–dA) and poly(dC–dG) and the other in the first intron comprised of poly(dG–dT).

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen I alpha2.

Immunogen Range: 471-520

Application

Anti-Collagen I α2 antibody has been used to quantify protein expression levels after western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Collagen I α2 (COL1A2) is essential to maintain elasticity of the vessel wall and is an important constituent of the extracellular matrix. Mutations in COL1A2 results in osteogenesis imperfecta (OI).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Collagen type I ?2 (COL1A2) is the susceptible gene for intracranial aneurysms.
Yoneyama T, et al.
Stroke, 35(2), 443-448 (2004)
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.
Spotila LD, et al.
Proceedings of the National Academy of Sciences of the USA, 88(12), 5423-5427 (1991)
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population.
Tian DZ, et al.
Genetics and molecular research : GMR, 15(1) (2015)
Jianhui Xu et al.
Proteomics. Clinical applications, 14(4), e1900112-e1900112 (2020-03-12)
Cystic vestibular schwannoma (CVS) and solid vestibular schwannoma (SVS) are subgroups of vestibular schwannoma (VS). The tumorigenesis of CVS and SVS have not been fully elucidated, and this study is designed to identify differentially expressed proteins involved in the tumorigenesis
Transcriptional regulation of the human type I collagen ?2 (COL1A2) gene by the combination of two dinucleotide repeats.
Akai J, et al.
Gene, 239(1), 65-73 (1999)
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