SAB4100235

Monoclonal Anti-SAMHD1 antibody produced in mouse

clone SAMHD1-A200, culture supernatant

• Synonym(s): AntiAGS5, AntiDCIP, AntiHD domain containing 1, AntiHDDC1, AntiMOP-5, AntiOTTHUMP00000030889, AntiSAM domain and HD domain 1, AntiSAM domain- and HD domain-containing protein 1, AntiSBBI88
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: SAMHD1-A200, monoclonal
• form: aqueous solution
• mol wt: antigen predicted mol wt 72 kDa
• species reactivity: human
• technique(s): western blot: suitable
• isotype: IgG1
• UniProt accession no.: Q9Y3Z3
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... SAMHD1(25939)

Description

General description

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with sterile alpha motif (SAM) and a dGTP-regulated dNTP hydrolase domain (HD). SAMHD1 gene is mapped to human chromosome 20q11.23.

Immunogen

SAMHD1 purified recombinant protein

Biochem/physiol Actions

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is a key enzyme, which controls the levels of dinucleotide triphosphates. It also acts as an immune response factor cum restriction factor for many virues including the human immunodeficiency virus (HIV) hepatitis B virus (HBV) and herpes simplex virus 1 (HSV-1). SAMHD1 interferon-stimulated gene (ISG) also regulates the human cytomegalovirus and papillomavirus life cycles. Mutation in the SAMHD1 leads to imbalance in dinucleotide levels and is implicated in Aicardi‐Goutières syndrome (AGS) Mutation in SAMHD1 along with Three Prime Repair Exonuclease 1 (TREX1) and Stimulator of interferon genes (STING) genes is also correlated to familial chilblain lupus (FCL).

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable