RAB0938
Phosphotyrosine BTK / Tyrosine-protein Kinase BTK ELISA Kit
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
technique(s)
ELISA: suitable
assay range
inter-assay cv: <10%
intra-assay cv: <12%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BTK(695)
General description
Bruton tyrosine kinase (BTK) belongs to the Tec family of kinases. It is expressed in multiple hematopoietic cells. It plays a role in B-cell activation, maturation, development, and B-cell receptor (BCR)-signaling. Mutations in the BTK gene are associated with an inherited disorder, X-linked agammaglobulinemia. The BTK gene is located on the human chromosome at Xq22.1.
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-BTK.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Kit Components Also Available Separately
Product No.
Description
SDS
- RABHRP6Phosphotyrosine ELISA HRP-StreptavidinSDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Bruton's Tyrosine Kinase (BTK) Is a Novel KMT2A Partner Gene
Zerkalenkova E
Blood (2019)
Bruton's Tyrosine Kinase (BTK) Is a Novel KMT2A Partner Gene
Zerkalenkova E
Blood (2019)
Sarah E M Herman et al.
Blood, 117(23), 6287-6296 (2011-03-23)
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse models its mutation has a relatively B cell-specific phenotype. Herein, we demonstrate that BTK protein
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