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R123

Sigma-Aldrich

RBI 257 maleate salt

solid

Synonym(s):

1-[4-Iodobenzyl]-4-[[2-[3-isopropoxy]pyridyl]-methylamino]piperidine maleate salt, p-Iodo-U-101,958 maleate salt

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About This Item

Empirical Formula (Hill Notation):
C21H28IN3O · C4H4O4
Molecular Weight:
581.44
MDL number:
MFCD01321055
UNSPSC Code:
12352200
PubChem Substance ID:
24899345

form

solid

color

white

solubility

H2O: 0.2 mg/mL
ethanol: 1 mg/mL
0.1 M HCl: 7 mg/mL
DMSO: 9 mg/mL

storage temp.

2-8°C

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)Oc1cccnc1N(C)C2CCN(CC2)Cc3ccc(I)cc3

Biochem/physiol Actions

High affinity D4 dopamine receptor ligand.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N S Kula et al.
European journal of pharmacology, 331(2-3), 333-336 (1997-07-23)
RBI-257 (1-[4-iodobenzyl]-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperid ine), the p-iodobenzyl analog of U-101,958 (1-benzyl-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperidine) had a lower dissociation constant (Ki = 0.3 vs. 2.7 nM) and higher selectivity than U-101,958 at dopamine D4 receptors, over dopamine D2 and D3 receptors in transfected cell membranes and
Compounds selective for dopamine receptor subtypes.
Kebabian, et al.
Drug Discovery Today, 2, 333-340 (1997)
F Henry et al.
Theriogenology, 83(8), 1373-1380 (2015-03-05)
From many endangered or threatened species which are expected to profit from assisted reproduction techniques, mainly epididymal sperm of dead or freshly castrated males are available. These sperm had contact to epididymal secretion products but not to seminal fluid components.

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