P4618
Anti-PUMA/bbc3, C-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Bcl-2 Binding Component 3, Anti-p53 Upregulated Modulator of Apoptosis
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About This Item
MDL number:
UNSPSC Code:
12352203
conjugate:
unconjugated
application:
ARR
WB
WB
clone:
polyclonal
species reactivity:
human, mouse
citations:
4
technique(s):
microarray: suitable
western blot: 1-2 μg/mL
western blot: 1-2 μg/mL
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
microarray: suitable
western blot: 1-2 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... BBC3(27113)
mouse ... Bbc3(170770)
Specificity
Using K562 or 3T3 cell lysates, the antibody recognizes a band at ~23 kDa. A lower band at ~16 kDa may be detected in MOLT4 and U937 cells, which may represent PUMA-β.
Immunogen
synthetic peptide corresponding to amino acids 180-193 of human PUMA-α.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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L Gangoda et al.
Cell death and differentiation, 21(11), 1815-1824 (2014-07-12)
Loss of function mutations in the Prkar1a gene are the cause of most cases of Carney complex disorder. Defects in Prkar1a are thought to cause hyper-activation of PKA signalling, which drives neoplastic transformation, and Prkar1a is therefore considered to be
Mustak Pirbhai et al.
The Journal of biological chemistry, 281(42), 31495-31501 (2006-08-31)
Chlamydia trachomatis has evolved a profound anti-apoptotic activity that may aid in chlamydial evasion of host defense. The C. trachomatis anti-apoptotic activity has been correlated with blockade of mitochondrial cytochrome c release, inhibition of Bax and Bak activation, and degradation
Jennifer Adamski et al.
PloS one, 8(6), e65304-e65304 (2013-06-21)
Survival rates from childhood cancer have improved dramatically in the last 40 years, such that over 80% of children are now cured. However in certain subgroups, including metastatic osteosarcoma, survival has remained stubbornly poor, despite dose intensive multi-agent chemotherapy regimens
Baharan Fekry et al.
Nature communications, 9(1), 4149-4149 (2018-10-10)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C16-ceramide. C16-ceramide tightly binds within the p53 DNA-binding domain (Kd ~ 60 nM), in close vicinity to the Box V
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