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P3043

Sigma-Aldrich

β-Propiolactone

Grade III, 85-90%

Synonym(s):

3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone

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About This Item

Empirical Formula (Hill Notation):
C3H4O2
CAS Number:
57-57-8
Molecular Weight:
72.06
EC Number:
200-340-1
MDL number:
MFCD00005169
UNSPSC Code:
12352200

type

Grade III

Assay

85-90%

refractive index

n20/D 1.412 (lit.)

bp

162 °C (lit.)

mp

−33 °C (lit.)

density

1.146 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

O=C1CCO1

InChI

1S/C3H4O2/c4-3-1-2-5-3/h1-2H2

InChI key

VEZXCJBBBCKRPI-UHFFFAOYSA-N

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Caution

Insoluble polymers may form during storage.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H315,H319,H330,H350

Hazard Classifications

Acute Tox. 2 Inhalation - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

158.0 °F - closed cup

Flash Point(C)

70 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
088K1098
058K1607
018K1460
085K1647
019H12361

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Marion Rusch et al.
Angewandte Chemie (International ed. in English), 50(42), 9838-9842 (2011-09-10)
Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.
Ying-Jie Lu et al.
Vaccine, 28(47), 7468-7475 (2010-09-23)
Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement
Natalija Budimir et al.
PloS one, 7(1), e30898-e30898 (2012-02-04)
The inability of seasonal influenza vaccines to effectively protect against infection with antigenically drifted viruses or newly emerging pandemic viruses underlines the need for development of cross-reactive influenza vaccines that induce immunity against a variety of virus subtypes. Therefore, potential
Anjeanette Roberts et al.
Viral immunology, 23(5), 509-519 (2010-10-05)
The immunogenicity and efficacy of β-propiolactone (BPL) inactivated whole virion SARS-CoV (WI-SARS) vaccine was evaluated in BALB/c mice and golden Syrian hamsters. The vaccine preparation was tested with or without adjuvants. Adjuvant Systems AS01(B) and AS03(A) were selected and tested
R Ramya et al.
Vaccine, 27(15), 2138-2143 (2009-04-10)
Rabies is an endemic, fatal zoonotic disease in the developing countries. Oral vaccination strategies are suitable for rabies control in developing countries. Studies were performed to investigate the suitability of poly(lactide-co-glycolide) (PLG) microspheres as an oral delivery system for beta-propiolactone
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