P2959
PD 142,893
≥97% (HPLC)
Synonym(s):
N-Acetyl-β-Phenyl-D-Phe-Leu-Asp-Ile-Ile-Trp
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About This Item
Empirical Formula (Hill Notation):
C50H65N7O10
CAS Number:
Molecular Weight:
924.09
MDL number:
UNSPSC Code:
12352200
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c2ccccc2)[C@@H](C)CC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(O)=O
Amino Acid Sequence
N-Acetyl-β-Phenyl-Phe-Leu-Asp-Ile-Ile-Trp
General description
Contains the conserved endothelin sequence, His-Leu-Asp-Ile-Ile-Trp, with His replaced by a bulky aromatic moiety.
Biochem/physiol Actions
Non-selective endothelin receptor antagonist.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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J Drimal et al.
European journal of pharmacology, 396(1), 19-22 (2000-05-24)
The characteristics of specific binding of human [125I]Tyr(13)-endothelin-(1-21), [125I]-Tyr(13)-Suc-[Glu(9),Ala(11, 15)]-endothelin-(8-21), ([125I]IRL-1620) and endothelin ET(A) receptor antagonist [125I]Tyr(3)-(N-[(hexahydro-1H-azepin-1-yl)carbonyl]-L-Leu]-1Me )-D-Trp ([125I]PD151242) (number of sites and their affinity) and proliferation responses to exogenous endothelin receptor agonists (endothelin-1 and the endothelin ET(B) receptor-selective, truncated
T D Warner et al.
British journal of pharmacology, 110(2), 777-782 (1993-10-01)
1. We have compared the receptors mediating the contractions of rings of rat thoracic aorta or rabbit pulmonary artery and rat stomach strips in response to the endothelin/sarafotoxin (ET/SX) family of peptides and to those mediating endothelium-dependent vasodilations within the
R L Schroeder et al.
Journal of cardiovascular pharmacology, 32(6), 935-943 (1998-12-30)
The purpose of this study was to determine whether vascular endothelial and vascular smooth-muscle endothelin ET(B) receptors could be quantitatively differentiated by PD 142893 (PD), SB 209670 (SB), and BQ 788 (BQ) in the same species by using closely matched
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