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M005

S-(+)-Deprenyl hydrochloride

solid

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About This Item

Empirical Formula (Hill Notation):
C13H17N · HCl
CAS Number:
4528-52-3
Molecular Weight:
223.74
UNSPSC Code:
12352200
PubChem Substance ID:
24896532
MDL number:
MFCD00069300
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form

solid

optical activity

[α]24/D +11.84°, c = 0.1 in H2O(lit.)

color

white

solubility

H2O: soluble

SMILES string

Cl.C[C@@H](Cc1ccccc1)N(C)CC#C

Biochem/physiol Actions

Less active enantiomer of deprenyl.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
011K4600

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J W Tetrud et al.
Science (New York, N.Y.), 245(4917), 519-522 (1989-08-04)
The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's disease, can be fully prevented in experimental animals by inhibiting monoamine oxidase B. On the basis of this observation, a double-blind, placebo-controlled study in patients with early
Keiko Inaba-Hasegawa et al.
Journal of neural transmission (Vienna, Austria : 1996), 120(3), 435-444 (2012-09-13)
Type B monoamine oxidase (MAO-B) is proposed to be involved in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease, through oxidative stress and synthesis of neurotoxins. MAO-B inhibitors, rasagiline and selegiline [(-)deprenyl], protect neuronal cells by direct intervention in
Chitra Sridar et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(12), 2256-2266 (2012-09-01)
Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is metabolized primarily by CYP2B6. The effect of selegiline on the enzymatic activity of human
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