K0889
Anti-Kinesin 5A antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
bovine, human, mouse
technique(s)
western blot: 0.4 μg/mL using mouse neuronal cell lysate and human retinal extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KIF5A(3798)
mouse ... Kif5a(16572)
Related Categories
General description
The gene KIF5A (kinesin family member 5A) is mapped to human chromosome 12. The encoded kinesin is expressed in all neurons, and present in neuronal cytoplasm, which includes the cell body, dendrites, and axon.
Immunogen
synthetic peptide corresponding to amino acid residues 1007-1027 from mouse kinesin 5A.
Application
Anti-Kinesin 5A antibody produced in rabbit has been used in immunofluorescence and immunohistochemistry[1].
Biochem/physiol Actions
The gene KIF5A (kinesin family member 5A) encodes a kinesin heavy chain that may be involved in the microtubule-dependent slow axonal transport of neurofilament proteins.
Mutations in this gene have been associated with hereditary spastic paraplegia.
Mutations in this gene have been associated with hereditary spastic paraplegia.
Physical form
Solution in phosphate buffered saline containing 1 mg/mL BSA and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.
Xia CH
The Journal of Cell Biology, 161, 55-66 (2003)
Ping Shi et al.
Biochimica et biophysica acta, 1802(9), 707-716 (2010-06-01)
Transport of material and signals between extensive neuronal processes and the cell body is essential to neuronal physiology and survival. Slowing of axonal transport has been shown to occur before the onset of symptoms in amyotrophic lateral sclerosis (ALS). We
Evan Reid et al.
American journal of human genetics, 71(5), 1189-1194 (2002-10-02)
We have identified a missense mutation in the motor domain of the neuronal kinesin heavy chain gene KIF5A, in a family with hereditary spastic paraplegia. The mutation occurs in the family in which the SPG10 locus was originally identified, at
Ingo Spitzbarth et al.
Brain and behavior, 6(7), e00472-e00472 (2016-06-02)
CDV-DL (Canine distemper virus-induced demyelinating leukoencephalitis) represents a spontaneously occurring animal model for demyelinating disorders. Axonopathy represents a key pathomechanism in this disease; however, its underlying pathogenesis has not been addressed in detail so far. This study aimed at the
S Schwarz et al.
Scientific reports, 10(1), 5380-5380 (2020-03-28)
Dogs share many chronic morbidities with humans and thus represent a powerful model for translational research. In comparison to rodents, the canine ganglioside metabolism more closely resembles the human one. Gangliosides are components of the cell plasma membrane playing a
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