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I0782

Sigma-Aldrich

Imazodan

≥99% (HPLC)

Synonym(s):

4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914

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About This Item

Empirical Formula (Hill Notation):
C13H12N4O
CAS Number:
84243-58-3
Molecular Weight:
240.26
MDL number:
MFCD00867109
UNSPSC Code:
41106305
PubChem Substance ID:
24278485

Assay

≥99% (HPLC)

color

yellow, powder

solubility

DMSO: 50 mg/mL, clear, yellow

SMILES string

O=C1CCC(=NN1)c2ccc(cc2)-n3ccnc3

InChI

1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)

InChI key

VXMYWVMXSWJFCV-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

Biochem/physiol Actions

Selective phoshodiesterase III (PDE3) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
052K3799

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R E Weishaar et al.
Journal of cyclic nucleotide and protein phosphorylation research, 11(7), 513-527 (1986-01-01)
Two approaches were taken to examine the role which the different forms of phosphodiesterase present in cardiac muscle play in regulating contractility. In an initial study, the effect of selective inhibitors of i) the calmodulin-stimulated phosphodiesterase (M & B 22
R P Steffen et al.
Journal of cardiovascular pharmacology, 8(3), 520-526 (1986-05-01)
The purpose of this study was to evaluate the effect of the new cardiotonic, imazodan (CI-914), on myocardial hemodynamics and oxygen consumption, and peripheral blood flow distribution. Organ blood flow was measured by the radiolabeled-microsphere-reference-withdrawal technique and myocardial oxygen consumption
J A Allert et al.
Journal of cardiovascular pharmacology, 16(1), 59-67 (1990-07-01)
Although recent studies indicate that MCI-154 exerts novel positive inotropic actions in heart muscle, the chronotropic properties of this new drug remain undefined. The present study compared the inotropic/chronotropic profile of MCI-154 with those of a nonselective beta 1/beta 2-agonist
R E Weishaar et al.
Cardiovascular drugs and therapy, 3(1), 29-42 (1989-03-01)
Intense efforts during the last decade to identify a useful positive inotropic agent to replace digitalis for the treatment of congestive heart failure have led to the discovery of several dozen potential substitutes, of which a number are currently undergoing
High-performance liquid chromatographic assay of imazodan, methylparaben and propylparaben in imazodan injection.
T Geria et al.
Journal of chromatography, 450(3), 407-413 (1988-10-26)
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