H9284
Hepatitis C virus NS3 antigen 22kDa
0.5-1.4 mg/mL, ≥90% (SDS-PAGE), recombinant, expressed in E. coli
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About This Item
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recombinant
expressed in E. coli
Quality Level
Assay
≥90% (SDS-PAGE)
mol wt
22 kDa
concentration
0.5-1.4 mg/mL
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
NS3 (nonstructural 3) proteinase is a non-structural protein, which is involved in the proteolytic processing of other non-structural proteins. T-cells which are specific towards the NS3 are crucial for regulating viremia.
Other Notes
HCV NS3 antigen [1450-1643]-poly-Histidine-tagged
Physical form
Solution in 8 M urea, 20 mM Tris-HCl, pH 8.0, and 200 mM imidazole.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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R A Love et al.
Cell, 87(2), 331-342 (1996-10-18)
During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3. The structure of NS3 proteinase from HCV BK strain was determined by
P Martin et al.
Journal of medical virology, 74(3), 397-405 (2004-09-16)
Interferon-gamma (IFN gamma)-producing CD8+ T cells have been shown to play a key role in the control or eradication of hepatitis C virus (HCV) infections. In particular, T cells specific of the non-structural protein 3 (NS3) are often associated with
Wenjing He et al.
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