α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.
C8982
α-Cyano-4-hydroxycinnamic acid
suitable for MALDI-TOF MS
Synonym(s):
α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
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| Size/SKU | Availability | Price |
|---|---|---|
10 x 10 mg | Check Cart for Availability | $357.00 |
About This Item
Linear Formula:
HOC6H4CH=C(CN)CO2H
CAS Number:
Molecular Weight:
189.17
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
248-879-1
Beilstein/REAXYS Number:
3271427
MDL number:
Form:
powder
form
powder
Quality Segment
analyte chemical class(es)
glycans, peptides, proteins
technique(s)
protein mass spectrometry: suitable
mp
245-250 °C (lit.)
suitability
suitable for MALDI-TOF MS
storage temp.
room temp
SMILES string
OC(=O)\C(=C\c1ccc(O)cc1)C#N
InChI
1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChI key
AFVLVVWMAFSXCK-VMPITWQZSA-N
General description
α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
Application
α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
ProteoMass is a trademark of Sigma-Aldrich Co. LLC
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This Item | |||
|---|---|---|---|
| description suitable for MALDI-TOF MS | description 99% | description suitable for matrix substance for MALDI-MS, Ultra pure | description ≥98% (TLC), powder |
| form powder | form solid | form solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) - | analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) - |
| suitability suitable for MALDI-TOF MS | suitability - | suitability suitable for matrix substance for MALDI-MS | suitability - |
| mp 245-250 °C (lit.) | mp 245-250 °C (lit.) | mp 245-250 °C | mp 245-250 °C (lit.) |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Skin Sens. 1B
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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