B7937

BSc3094 monohydrobromide

≥98% (HPLC)

• Synonym(s): 2-[4-(4-Nitrophenyl)-2-thiazolyl]hydrazide-1H-benzimidazole-6-carboxylic acid monohydrobromide
• Empirical Formula (Hill Notation): C₁₇H₁₂N₆O₃S·HBr
• CAS Number: 1173021-98-1
• Molecular Weight: 461.29
• NACRES: NA.25
• PubChem Substance ID: 329773303
• UNSPSC Code: 12352200
• MDL number: MFCD12912398
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• solubility: DMSO: 22 mg/mL
• storage temp.: 2-8°C
• SMILES string: Br.[O-][N+](=O)c1ccc(cc1)-c2csc(NNC(=O)c3ccc4[nH]cnc4c3)n2
• InChI: 1S/C17H12N6O3S.BrH/c24-16(11-3-6-13-14(7-11)19-9-18-13)21-22-17-20-15(8-27-17)10-1-4-12(5-2-10)23(25)26;/h1-9H,(H,18,19)(H,20,22)(H,21,24);1H
• InChI key: HVNYYJJWBWMGCO-UHFFFAOYSA-N

Description

Application

BSc3094 is used in tau protein amyloidogenicity/tauopathy research to study the processes of tau aggregation and cross-linking in neurodegenerative disease development.

Biochem/physiol Actions

BSc3094 is a potent inhibitor of tau aggregation and dissolves preformed tau paired helical filaments. BSc3094 interacts closely with the tau protein at the edge involving protons I-IV, while the second attachment site seems to be at the nitro group. In N2A cells (model system for tau aggregation), BSc3094 exhibited low toxicity.

BSc3094 is a potent inhibitor of tau aggregation.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H319
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Faceshields, Gloves