B6060

BVT.948

Name: BVT.948
Brand: SIGMA
Price: 263 USD

≥98% (HPLC), solid

Synonym(s):

4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione

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1 MG

$263.00

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₁NO₃

CAS Number:

39674-97-0

Molecular Weight:

241.24

NACRES:

NA.77

PubChem Substance ID:

24724422

UNSPSC Code:

12352200

MDL number:

MFCD00616487

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated, protect from light, under inert gas

Key Documents

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InChI

1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3

SMILES string

CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12

InChI key

BAQXWJQSUXZVIP-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light, under inert gas

color

red

solubility

DMSO: 18 mg/mL, H₂O: insoluble

storage temp.

−20°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

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This Item	V4515	L4170	S8442
Sigma-Aldrich B6060 BVT.948	Sigma-Aldrich V4515 VU0238429	Sigma-Aldrich L4170 LDN-57444	Sigma-Aldrich S8442 SU 5416
form solid	form powder	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 18 mg/mL, H₂O: insoluble	solubility DMSO: ≥20 mg/mL	solubility DMSO: 16 mg/mL	solubility DMSO: 20 mg/mL, clear (warmed), H₂O: insoluble
storage condition desiccated, under inert gas, protect from light	storage condition -	storage condition desiccated, protect from light	storage condition -

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Chlorophyll a Fluorescence Parameters of Hulled and Hull-less Barley (Hordeum vulgare L.) DH Lines Inoculated with Fusarium culmorum.

Tomasz Warzecha et al.

The plant pathology journal, 35(2), 112-124 (2019-04-23)

Barley worldwide is affected seriously by Fusarium seedling blight (FSB) and Fusarium head blight (FHB) diseases caused by the Fusarium species. The objective of this study was to facilitate the resistance of hulled and hull-less barley at different growth stages

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