B4311

BF-170 hydrochloride

≥98% (HPLC), solid

• Synonym(s): 2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride
• Empirical Formula (Hill Notation): C₁₅H₁₂N₂ · HCl
• CAS Number: 22191-97-5
• Molecular Weight: 256.73
• MDL number: MFCD08705340
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891766
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated; protect from light; under inert gas
• color: orange
• solubility: H₂O: 10 mg/mL
• storage temp.: −20°C
• SMILES string: Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2
• InChI: 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
• InChI key: UYYPMQOFLJHJAW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC₅₀ = 221 nM vs. EC₅₀ = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

Caution

Product is air sensitive, store under inert gas.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H318,H335
• Precautionary Statements: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves