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A7712

Sigma-Aldrich

Amyloid β-Protein Fragment 1-43

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About This Item

Empirical Formula (Hill Notation):
C207H318N56O62S
CAS Number:
Molecular Weight:
4615.14
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

form

powder

Quality Level

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... APP(351)

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr

Biochem/physiol Actions

Primary constituent of senile plaques and cerebrovascular deposits in Alzheimer′s disease and Down′s syndrome

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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C J Pike et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(4), 1676-1687 (1993-04-01)
The progressive neurodegeneration of Alzheimer's disease has been hypothesized to be mediated, at least in part, by beta-amyloid protein. A relationship between the aggregation state of beta-amyloid protein and its ability to promote degeneration in vitro has been previously suggested.

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