The immunogen used to make this antibody is N-terminal.
475R-9
INSM1 (MRQ-70) Rabbit Monoclonal Antibody
Synonym(s):
Insulinoma-associated protein 1
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About This Item
UNSPSC Code:
12352203
Pricing and availability is not currently available.
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biological source
rabbit
Quality Level
100
500
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
MRQ-70, monoclonal
description
For In Vitro Diagnostic Use in Select Regions
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (475R-94)
vial of 0.1 mL concentrate Research Use Only (475R-94-RUO)
vial of 0.5 mL concentrate (475R-95)
vial of 1.0 mL concentrate (475R-96)
vial of 1.0 mL concentrate Research Use Only (475R-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (475R-97)
vial of 7.0 mL pre-dilute ready-to-use (475R-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)
manufacturer/tradename
Cell Marque™
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
isotype
IgG
control
pancreas
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Related Categories
General description
Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor1. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression5-6.
Quality
United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO
Canada - RUO
European Union - IVD
Japan - RUO
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
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Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Legal Information
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Mathias S Gierl et al.
Genes & development, 20(17), 2465-2478 (2006-09-05)
The pancreatic and intestinal primordia contain epithelial progenitor cells that generate many cell types. During development, specific programs of gene expression restrict the developmental potential of such progenitors and promote their differentiation. The Insm1 (insulinoma-associated 1, IA-1) gene encodes a
Lilla M Farkas et al.
Neuron, 60(1), 40-55 (2008-10-23)
Basal (intermediate) progenitors are the major source of neurons in the mammalian neocortex. The molecular machinery governing basal progenitor biogenesis is unknown. Here, we show that the zinc-finger transcription factor Insm1 (insulinoma-associated 1) is expressed specifically in progenitors undergoing neurogenic
Sanjay Mukhopadhyay et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(1), 100-109 (2018-08-30)
Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of
Jason N Rosenbaum et al.
American journal of clinical pathology, 144(4), 579-591 (2015-09-20)
Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms, which are sometimes malignant, although predicting metastasis is difficult. INSM1 is a transcription factor expressed transiently in embryonic neuroendocrine (NE) tissue, thought to coordinate termination of cell division with differentiation of NE and neuroepithelial
Jason N Rosenbaum et al.
Neural development, 6, 6-6 (2011-02-03)
Insm1 is a zinc-finger transcription factor transiently expressed throughout the developing nervous system in late progenitors and nascent neurons. Insm1 is also highly expressed in medulloblastomas and other neuroendocrine tumors. We generated mice lacking the Insm1 gene and used them
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