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22049

Sigma-Aldrich

λ-Carrageenan

plant mucopolysaccharide

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About This Item

CAS Number:
9064-57-7
EC Number:
232-953-5
MDL number:
MFCD00151513
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

plant

form

solid

color

light yellow

storage temp.

room temp

InChI

1S/C24H42O39S6/c25-1-5-9(27)11(29)18(61-67(42,43)44)22(54-5)57-15-8(4-52-65(36,37)38)56-23(19(13(15)31)62-68(45,46)47)59-16-10(28)6(2-26)55-24(20(16)63-69(48,49)50)58-14-7(3-51-64(33,34)35)53-21(32)17(12(14)30)60-66(39,40)41/h5-32H,1-4H2,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)/p-6/t5-,6-,7-,8-,9+,10+,11+,12+,13+,14+,15+,16+,17-,18-,19-,20-,21+,22+,23-,24+/m1/s1

InChI key

CFLYIPGVTFOQCI-SQESNNFJSA-H

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General description

Carrageenans are mucopolysaccharides from the cell walls of the red algae. They are anionic linear polymers composed of 1,3α-1,4β-galactans having one (κ-), two (ι-) or three (λ-) sulfates per disaccharide unit. In ionic solutions, κ- and ι-carrageenans self-associate into helical structures that form rigid or flexible gels, respectively. λ-carrageenans do not form helices and are non-gelling. Carrageenans are used commercially as thickeners and stabilizing agents.
non-gelling at 1% in 0.2 M KCl-solution

Application

Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages. Non-gelling λ-carrageenan is used to induce inflammation and inflammatory pain in the rodent hindpaw or air pouch models. More recently carrageenan has been injected directly into the joints of rodents to model arthritic pain and inflammation.

Analysis Note

solubility:
10 mg/mL in H2O : clear to very hazy, colorless to faint yellow

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBP8978V
BCBP7001V
BCBP3274V
BCBP3273V
BCBN6085V

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Vanessa Pirrone et al.
Virology journal, 9, 33-33 (2012-01-28)
Continued efforts are being directed toward the development of microbicides that will be used to reduce or eliminate the risk of HIV-1 sexual transmission. Unfortunately, clinical trials involving polyanion-containing microbicide formulations, including Carraguard (λ-carrageenan [LC]) and Ushercell (cellulose sulfate [CS])
Influence of dicephalic ionic surfactant interactions with oppositely charged polyelectrolyte upon the In vitrodye release from oil core nanocapsules.
Bazylinska U, Skrzela R, et al.
Bioelectrochemistry, doi: 10-doi: 10 (2011)
Refat M Hassan et al.
Carbohydrate research, 346(14), 2260-2267 (2011-08-30)
The kinetics of oxidation of iota- and lambda-carrageenan as sulfated carbohydrates by permanganate ion in aqueous perchlorate solutions at a constant ionic strength of 2.0 mol dm(-3) have been investigated spectrophotometrically. The pseudo-first-order plots were found to be of inverted
Tetsuro Nikai et al.
Pain, 139(3), 533-540 (2008-08-30)
Sumatriptan and the other triptan drugs target the serotonin receptor subtypes1B, 1D, and 1F (5-HT(1B/D/F)), and are prescribed widely in the treatment of migraine. An anti-migraine action of triptans has been postulated at multiple targets, within the brain and at
Li Zhang et al.
Asian journal of andrology, 21(4), 351-359 (2019-01-04)
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