PHR1349

Beta Alanine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): β-Alanine, β-Ala, 3-Aminopropionic acid
• Linear Formula: NH₂CH₂CH₂COOH
• CAS Number: 107-95-9
• Molecular Weight: 89.09
• Beilstein: 906793
• EC Number: 203-536-5
• MDL number: MFCD00008200
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823333
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1012495
• API family: beta-alanine
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 202 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: NCCC(O)=O
• InChI: 1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)
• InChI key: UCMIRNVEIXFBKS-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Beta Alanine is a non-protein amino acid, widely available in plants as one of the precursors for the essential vitamin, pantothenate. It exhibits behavior of an osmoprotectant in microbial assays. It is also the precursor for beta-alanine betaine in the plant family Plumbaginaceae.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

β-Alanine, a β−amino acid, is a component of pantothenic acid and the rate-limiting amino acid in the biosynthesis of the histidinyl antioxidant dipeptides carnosine and anserine. Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-Alanine flux plays a cytoprotective role by supporting the osmotic stability of marine organisms, preimplantation mouse embryos and mammalian cells exposed to hypoxic stress.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3952 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable