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C1905000

Chlorpropamide

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-(p-Chlorobenzenesulfonyl)-3-propylurea

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About This Item

Empirical Formula (Hill Notation):
C10H13ClN2O3S
CAS Number:
94-20-2
Molecular Weight:
276.74
MDL number:
MFCD00079004
UNSPSC Code:
41116107
PubChem Substance ID:
329774914
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

chlorpropamide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

InChI

1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

InChI key

RKWGIWYCVPQPMF-UHFFFAOYSA-N

Gene Information

human ... ABCC8(6833) , KCNJ11(3767)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorpropamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Product No.
Description
Pricing

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361f

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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The chlorpropamide alcohol flush.
P G Wiles et al.
Clinical science (London, England : 1979), 67(4), 375-381 (1984-10-01)
Jing Li et al.
Critical care medicine, 42(12), e734-e740 (2014-11-18)
Cooling following cardiac arrest can improve survival significantly. However, delays in achieving target temperature may decrease the overall benefits of cooling. Here, we test whether lipid emulsion, a clinically approved drug reported to exert cardioprotection, can rescue heart contractility in
[Flush induced by chlorpropamide-alcohol (CAF): a genetic marker of diabetes mellitus or an undesirable effect of the drug?].
J Sabán et al.
Revista clinica espanola, 176(3), 107-111 (1985-02-01)
Chlorpropamide--alcohol flush: the case in favour.
C Johnston et al.
Diabetologia, 26(1), 1-5 (1984-01-01)
Sergey E Kichanov et al.
Journal of pharmaceutical sciences, 104(1), 81-86 (2014-11-14)
The crystal structure and vibrational spectra of the chlorpropamide have been studied by means of the X-ray diffraction and Raman spectroscopy at pressures up to 24.6 and 4.4 GPa, respectively. Two polymorphic phase transitions, between initial orthorhombic form-A and a
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