8.52051

Fmoc-Tyr-OH

Novabiochem^®

• Synonym(s): Fmoc-Tyr-OH, N-α-Fmoc-L-tyrosine
• Empirical Formula (Hill Notation): C₂₄H₂₁NO₅
• CAS Number: 92954-90-0
• Molecular Weight: 403.43
• MDL number: MFCD00134890
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥93.0% (acidimetric); ≥95.0% (HPLC); ≥96% (TLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 175-185 °C
• application(s): peptide synthesis
• functional group: hydroxyl
• storage temp.: 2-30°C
• InChI: 1S/C24H21NO5/c26-16-11-9-15(10-12-16)13-22(23(27)28)25-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22,26H,13-14H2,(H,25,29)(H,27,28)/t22-/m0/s1
• InChI key: SWZCTMTWRHEBIN-QFIPXVFZSA-N

Description

General description

A useful derivative for the synthesis of phosphotyrosine peptides by the global Fmoc SPPS phosphorylation methodology ^[1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] E. A. Kitas, et al. (1991) Helv. Chim. Acta, 74, 1314.

Linkage

Replaces: 04-12-1105

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 96 %
Purity (TLC(157B)): ≥ 96 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 93.0 %
Water (K. F.): ≤ 2.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable