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401483

Millipore

IKK-2 Inhibitor VI - CAS 354811-10-2 - Calbiochem

Synonym(s):

(5-Phenyl-2-ureido)thiophene-3-carboxamide

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About This Item

Assay

≥98% (HPLC)

Quality Level

form

solid

potency

13 nM IC50

color

off-white

solubility

DMSO: 50 mg/mL

General description

An ureido-thiophenecarboxamide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 13 nM).

Biochem/physiol Actions

IKK-2

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Storage Class Code

10-13 - German Storage Class 10 to 13


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Andrew Baxter et al.
Bioorganic & medicinal chemistry letters, 14(11), 2817-2822 (2004-05-06)
A hit-to-lead optimisation programme was carried out on the thiophenecarboxamide high throughput screening hits 1 and 2 resulting in the discovery of the potent and orally bioavailable IKK-2 inhibitor 22.

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