493805

5-(Ethylthio)-1H-tetrazole

95%

• Synonym(s): 5-(Ethylthio)-2H-tetrazole, 5-Ethylsulfanyl-2H-tetrazole
• Empirical Formula (Hill Notation): C₃H₆N₄S
• CAS Number: 89797-68-2
• Molecular Weight: 130.17
• MDL number: MFCD00068733
• UNSPSC Code: 12352100
• PubChem Substance ID: 24872861
• NACRES: NA.22

Properties

• Assay: 95%
• mp: 84-90 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CCSc1nnn[nH]1
• InChI: 1S/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7)
• InChI key: GONFBOIJNUKKST-UHFFFAOYSA-N

Description

General description

5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis.

Application

• Solid-Phase Synthesis of Symmetrical Dinucleoside Phosphodiesters: Explores the efficiency of 5-(Ethylthio)-1H-tetrazole in the solid-phase synthesis of dinucleoside phosphodiesters, underlining its significance in the streamlined production of biologically relevant molecules (Ahmadibeni et al., 2007).
• Synthesis, Deprotection, Analysis, and Purification of RNA and Ribozymes: Utilizes 5-(Ethylthio)-1H-tetrazole in the synthesis and processing of RNA and ribozymes, highlighting its critical role in molecular biology and genetic engineering research (Wincott et al., 1995).

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H314,H335
• Precautionary Statements: P260 - P271 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH044
• Storage Class Code: 4.1A - Other explosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves