361194
trans-3-Bromo-N-ethylcinnamamide
technical grade, 90%
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About This Item
Linear Formula:
BrC6H4CH=CHCONHC2H5
CAS Number:
Molecular Weight:
254.12
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
grade
technical grade
Assay
90%
mp
89-91 °C (lit.)
SMILES string
CCNC(=O)\C=C\c1cccc(Br)c1
InChI
1S/C11H12BrNO/c1-2-13-11(14)7-6-9-4-3-5-10(12)8-9/h3-8H,2H2,1H3,(H,13,14)/b7-6+
InChI key
LDCXGZCEMNMWIL-VOTSOKGWSA-N
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Epilepsia, 30(4), 422-429 (1989-07-01)
This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome
E A Lane et al.
Journal of pharmacokinetics and biopharmaceutics, 13(4), 373-386 (1985-08-01)
A previous study of the metabolic fate of cinromide (3-bromo-N-ethylcinnamamide) in rhesus monkey established that half of a dose is metabolized by N-deethylation to an active metabolite, 3-bromocinnamamide. Both cinromide and its proximal metabolite can be metabolized by amide hydrolysis
Variability in the determination of fraction metabolized in a triangular metabolic problem and its resolution with stable isotope methodology.
H Lin et al.
Journal of pharmaceutical sciences, 73(2), 285-287 (1984-02-01)
K Bernásková et al.
Physiologia Bohemoslovaca, 37(2), 123-130 (1988-01-01)
The effects of cinromide on two types of metrazol-induced seizures were studied in 236 male rats aged 7, 12, 18, 25 and 90 days. Cinromide was administered intraperitoneally in a dose of 25 or 50 mg.kg-1 30 min before a
G H Fromm et al.
Epilepsia, 24(4), 394-400 (1983-08-01)
The effect of the experimental anticonvulsant cinromide (3-bromo-N-ethylcinnamamide) on various inhibitory and excitatory mechanisms was investigated in the trigeminal nucleus of cats. Intravenous administration of 20-80 mg/kg cinromide depressed excitatory transmission and facilitated segmental inhibition to the same extent as
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