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Deoxycorticosterone acetate

98%

Synonym(s):

11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O4
CAS Number:
56-47-3
Molecular Weight:
372.50
Beilstein:
2570798
EC Number:
200-275-9
MDL number:
MFCD00003660
UNSPSC Code:
12352200
PubChem Substance ID:
329753238

Assay

98%

form

solid

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

InChI key

VPGRYOFKCNULNK-ACXQXYJUSA-N

Gene Information

human ... NR3C2(4306)

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Certificates of Analysis (COA)

Lot/Batch Number
16325HR
10904BF
08425BF
03715TZ
12009BF

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Saad Lahlou et al.
Fundamental & clinical pharmacology, 17(3), 323-330 (2003-06-14)
The present study investigated the hypotensive responses to intravenous (i.v.) treatment with the essential oil of Alpinia zerumbet (EOAZ) and its main constituent, terpinen-4-ol (Trp-4-ol), in the experimental model of deoxycorticosterone-acetate (DOCA)-salt hypertensive rat. In both DOCA-salt hypertensive and uninephrectomized
J P Davis et al.
Clinical science (London, England : 1979), 81(1), 73-78 (1991-07-01)
1. Hypertension was induced in male Sprague-Dawley rats by left unilateral nephrectomy and deoxycorticosterone acetate--salt administration. After 5 weeks, arterial systolic blood pressure was significantly elevated in these animals (191.5 +/- 6.0 mmHg, mean +/- SD, n = 17) compared
Riccardo Candido et al.
American journal of hypertension, 18(6), 844-850 (2005-06-01)
The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS). Five groups, 10 animals each, were studied. One group served as a
Ashok Jadhav et al.
Experimental biology and medicine (Maywood, N.J.), 234(7), 764-778 (2009-05-12)
In hypertension, elevated levels of oxidative/inflammatory mediators including nuclear factor kappaB (NF-kappaB), activating protein (AP-1), c-Jun-NH2-terminal kinase (JNK), and cell-regulatory proteins such as transforming growth factor beta (TGF-beta), trigger the mobilization of extracellular matrix (ECM) leading to fibrosis, hypertrophy and
Björn Friedrich et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 22(5-6), 465-474 (2008-12-18)
Renal fibrosis is characterized by excessive accumulation of extracellular matrix proteins. Recent findings show that transforming growth factor-beta (TGF-beta) induces a rapid but transient expression of early growth response gene-1 (Egr-1) by skin fibroblasts. The present study aims to define
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