CHRNA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
Synonyms:
CHRNA7-2, NACHRA7
Species:
Human CHRNA7 (1139), Mouse Chrna7 (11441), Rat Chrna7 (25302), domestic cat CHRNA7 (751113), Zebrafish chrna7 (394199), dog CHRNA7 (488696), cow CHRNA7 (282178), Horse CHRNA7 (100060521), chicken CHRNA7 (374001), naked mole-rat Chrna7 (101720562)
UniProtKB ID:
Gene ID:
- Human(1139) Summary: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
- Mouse(11441) cholinergic receptor, nicotinic, alpha polypeptide 7
- Rat(25302) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- domestic cat(751113) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- Zebrafish(394199) cholinergic receptor, nicotinic, alpha polypeptide 7
- dog(488696) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- cow(282178) cholinergic receptor, nicotinic, alpha 7
- Horse(100060521) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- chicken(374001) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- naked mole-rat(101720562) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- domestic guinea pig(100720640) cholinergic receptor, nicotinic, alpha 7 (neuronal)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Agonist
Product Number
Description
Species
(−)-Nicotine solution, 1.0 mg/mL, analytical standard, for drug analysis,
Species
human, mouse, rat
Small Molecule - Antagonist
Product Number
Description
Species
(−)-Nicotine solution, 1.0 mg/mL, analytical standard, for drug analysis,
Species
human, mouse, rat
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Nicotinic Acetylcholine Receptor α7 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Small Molecule - Blocker
esiRNA
Product Number
Description
Species