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  • CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Nature neuroscience (2013-05-28)
Elizabeth M Bradshaw, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
PMID23708142
ABSTRACT

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

MATERIALS
Product Number
Brand
Product Description
31420
Supelco
Dextran from Leuconostoc mesenteroides, for GPC, analytical standard, Mw 50,000
31430
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Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
31417
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 5,000
31418
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 12,000
00270
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Dextran, analytical standard, for GPC, 12,000
00893
Supelco
Dextran, analytical standard, for GPC, 150,000
00896
Supelco
Dextran, analytical standard, for GPC, 670,000
00268
Supelco
Dextran, analytical standard, for GPC, 1,000
00892
Supelco
Dextran, analytical standard, for GPC, 80,000
D8821
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Dextran from Leuconostoc mesenteroides, average mol wt 60,000-76,000
31419
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000
31425
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000
31424
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Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 410,000
00891
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Dextran, analytical standard, for GPC, 50,000
00895
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Dextran, analytical standard, for GPC, 410,000
31387
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Dextran from Leuconostoc spp., Mr 15,000-25,000
00269
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Dextran, analytical standard, for GPC, 5,000
00271
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Dextran, analytical standard, for GPC, 25,000
00894
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Dextran, analytical standard, for GPC, 270,000
31397
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, Mr ~60,000
31390
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~70,000
31394
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Dextran, enzymatic synth.
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Dextran from Leuconostoc spp., Mr 450,000-650,000
31388
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Dextran from Leuconostoc mesenteroides, Mr ~200,000
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Dextran from Leuconostoc spp., Mr ~100,000
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Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000
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Dextran from Leuconostoc mesenteroides, average mol wt 35,000-45,000
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