CRM01342
Etridiazole
certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Synonym(s):
5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole, Ethazol
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About This Item
Empirical Formula (Hill Notation):
C5H5Cl3N2OS
CAS Number:
Molecular Weight:
247.53
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade
certified reference material
TraceCERT®
Quality Level
product line
TraceCERT®
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
storage temp.
2-8°C
SMILES string
CCOc1nc(ns1)C(Cl)(Cl)Cl
InChI
1S/C5H5Cl3N2OS/c1-2-11-4-9-3(10-12-4)5(6,7)8/h2H2,1H3
InChI key
KQTVWCSONPJJPE-UHFFFAOYSA-N
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General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com
Etridiazole is a fungicide primarily effective against oomycetes and widely used in controlling Pythium and Phytophthora species on agricultural and horticultural crops. Etridiazole causes the hydrolysis of cell membrane phospholipids into free fatty acids and lysophosphatides, leading to the lysis of membranes in fungi.
The drinking water standards have regulated a maximum contaminant level (MCL) for Etridiazole in treated waters. Australian drinking water guidelines set an MCL at 0.1 mg L-1. The European Union (EU) drinking water standards regulate a level for any pesticide at 0.0001 mg L-1 and the sum of all pesticides at 0.0005 mg L-1.
Etridiazole was included in Annex I to Directive 91/414/EEC on 1 June 2014 by Commission Directive 2011/29/EU and has been deemed to be approved under Regulation (EC) No 1107/2009, as per Commission Implementing Regulation (EU) No 540/2011, as amended by Commission Implementing Regulation (EU) No 541/2011. The inclusion in Annex I of Directive 91/414/EEC was restricted to uses of Etridiazole as a fungicide in non-soil bound systems in greenhouse. Maximum residue levels (MRLs) have been set according to Reg (EU) 2017/1777 for Etridiazole for various products of plant and animal origin from 0.05 to 0.4 mg/kg.
Etridiazole is a fungicide primarily effective against oomycetes and widely used in controlling Pythium and Phytophthora species on agricultural and horticultural crops. Etridiazole causes the hydrolysis of cell membrane phospholipids into free fatty acids and lysophosphatides, leading to the lysis of membranes in fungi.
The drinking water standards have regulated a maximum contaminant level (MCL) for Etridiazole in treated waters. Australian drinking water guidelines set an MCL at 0.1 mg L-1. The European Union (EU) drinking water standards regulate a level for any pesticide at 0.0001 mg L-1 and the sum of all pesticides at 0.0005 mg L-1.
Etridiazole was included in Annex I to Directive 91/414/EEC on 1 June 2014 by Commission Directive 2011/29/EU and has been deemed to be approved under Regulation (EC) No 1107/2009, as per Commission Implementing Regulation (EU) No 540/2011, as amended by Commission Implementing Regulation (EU) No 541/2011. The inclusion in Annex I of Directive 91/414/EEC was restricted to uses of Etridiazole as a fungicide in non-soil bound systems in greenhouse. Maximum residue levels (MRLs) have been set according to Reg (EU) 2017/1777 for Etridiazole for various products of plant and animal origin from 0.05 to 0.4 mg/kg.
Application
The certified reference material can be used for the following:
- To evaluate the teratogenic and developmental toxic effects of etridiazole on zebrafish embryos
- Screening potential endophytic biofertilizers with fungicides tolerance and plant growth-promoting characteristics
- To investigate the photodegradation of etridiazole by UV radiation at 254 nm during drinking water treatment
- To determine the adsorption and desorption behavior of etridiazole and oxamyl on polyethylene sheets and polyvinyl chloride tubing used in horticulture
- To develop a selective and sensitive analytical method for the determination of a carboxylic and a mercapturic acid metabolite of etridiazole in urine
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
310.1 °F - open cup
Flash Point(C)
154.5 °C - open cup
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Alba Brancato et al.
EFSA journal. European Food Safety Authority, 15(3), e04736-e04736 (2017-03-09)
In accordance with Article 6 of Regulation (EC) No 396/2005, the evaluating Member State (EMS), the Netherlands, received an application from Arysta LifeScience Great Britain Limited to modify the existing maximum residue levels (MRLs) for the active substance etridiazole in various
Teratogenic and developmental toxic effects of etridiazole on zebrafish (Danio rerio) embryos
Vasamsetti BMK
Applied Biological Chemistry, 1-10 null
Adsorption experiments of etridiazole and oxamyl on polyethylene sheets and poly (vinyl chloride) tubing used in horticulture
Vuik J, et al.
Journal of Agricultural and Food Chemistry, 328-330 null
Screening of Rice Endophytic Biofertilizers with Fungicide Tolerance and Plant Growth-Promoting Characteristics
Shen FT, et al.
Sustainable Cities and Society, 1133 null
R T van Welie et al.
Archives of toxicology, 65(8), 625-632 (1991-01-01)
Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analytical procedures to determine etridiazole, the carboxylic acid ET-CA and the mercapturic acid ET-MA in
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