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Merck

SRP5220

Sigma-Aldrich

KAT8 (2-467), GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

FLJ14040, KAT8, MOF, MYST1, hMOF

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About This Item

CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.32

Pricing and availability is not currently available.

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~83 kDa

NCBI accession no.

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... KAT8(84148)

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51483A2715Y0626
suitability

nonselective for Candida spp., nonselective for Saccharomyces spp., nonselective for Pichia spp., nonselective for Zygosaccharomyces spp.

suitability

fungi, selective by low pH for Candida spp., selective by low pH for Pichia spp., selective by low pH for Saccharomyces spp., selective by low pH for Zygosaccharomyces spp., selective by low pH for molds (General Media), selective by low pH for yeasts (General Media)

suitability

nonselective for Saccharomyces spp.

suitability

nonselective for Candida spp., nonselective for Pichia spp., nonselective for Saccharomyces spp., nonselective for Zygosaccharomyces spp., yeasts

technique(s)

microbe id | utilization test: suitable, microbiological culture: suitable

technique(s)

microbe id | susceptibility testing: suitable, microbe id | utilization test: suitable, microbiological culture: suitable

technique(s)

microbe id | susceptibility testing: suitable, microbiological culture: suitable

technique(s)

microbe id | utilization test: suitable, microbiological culture: suitable

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

application(s)

clinical testing
food and beverages
life science and biopharma, microbiology

application(s)

agriculture
clinical testing
environmental
food and beverages
pharmaceutical, microbiology

application(s)

clinical testing
food and beverages, microbiology

application(s)

food and beverages
microbiology

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

room temp

General description

Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). MYST1 has a chromodomain that is involved in protein-protein interactions and targeting transcriptional regulators to the chromatin.[1][2]

Biochem/physiol Actions

Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) was originally isolated as a human immunodeficiency virus-1 (HIV-1) TAT-interactive protein, which plays important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. MYST1 is also involved in ataxia-telangiectasia mutated (ATM) function. It acetylates histone 4-lysine 16 (H4K16). The protein is a modulator of embryonic stem cells and an epigenetic regulator. It has been associated with gastric carcinoma.[3][1][4]

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells.
Mu X
Cellular Reprogramming, 17(4), 259-267 (2015)
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Gupta A
Cell Reports, 8(1), 177-189 (2014)
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.
Thomas T
Molecular and Cellular Biology, 28(16), 5093-5105 (2008)
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L
International Journal of Oncology, 46(6), 2535-2545 (2015)
Arun Gupta et al.
Molecular and cellular biology, 25(12), 5292-5305 (2005-06-01)
We have determined that hMOF, the human ortholog of the Drosophila MOF gene (males absent on the first), encoding a protein with histone acetyltransferase activity, interacts with the ATM (ataxia-telangiectasia-mutated) protein. Cellular exposure to ionizing radiation (IR) enhances hMOF-dependent acetylation

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