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SML3906

Sigma-Aldrich

CNS-11

≥98% (HPLC)

Synonym(s):

3-Oxo-N-(2,4,6-trimethylphenyl)indeno[1,2,3-de]phthalazine-2(3H)-acetamid, N-mesityl-2-(3-oxoindeno[1,2,3-de]phthalazin-2(3H)-yl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C25H21N3O2
CAS Number:
445218-34-8
Molecular Weight:
395.45
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

O=C1C2=C(C(C3=C4C=CC=C3)=NN1CC(NC5=C(C)C=C(C)C=C5C)=O)C4=CC=C2

Biochem/physiol Actions

Brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models.



CNS-11 is brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11 inhibits intracellular seeding of a-synuclein fibrils in biosensor cells—HEK293T cells. C-11 reduces number of a-synuclein aggregates in C. elegans model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro
Nature Communications, 13(1), 5451-5451 (2022)
Kevin A Murray et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(7), e2217835120-e2217835120 (2023-02-10)
The amyloid aggregation of alpha-synuclein within the brain is associated with the pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including multiple system atrophy (MSA). Alpha-synuclein aggregates are a major therapeutic target for treatment of these diseases. We identify

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