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SML2385

Sigma-Aldrich

Andrastin A

≥95% (HPLC)

Synonym(s):

(3β,5β,8α,9β,10α,13α)-3β-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):
C28H38O7
CAS Number:
174232-42-9
Molecular Weight:
486.60
MDL number:
MFCD28898503
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

form

powder

color

white to beige

storage temp.

−20°C

InChI

1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18?,19-,20?,25?,26+,27+,28?/m0/s1

InChI key

GRBXNADBNJGZRK-BCMOVVIDSA-N

Biochem/physiol Actions

Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anticancer activity. It has been shown to inhibit the farnesyltransferase activity of the oncogenic Ras proteins and inhibit the efflux of anticancer drugs from multidrug-resistant cancer cells.
Farnesyltransferase inhibitor with anticancer activity; mycotoxin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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