SML1496

Buformin hydrochloride

≥98% (HPLC)

• Synonym(s): 1-Butylbiguanide hydrochloride, N-Butyl-imidodicarbonimidic diamide hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₅N₅ · HCl
• CAS Number: 1190-53-0
• Molecular Weight: 193.68
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 25 mg/mL, clear
• storage temp.: −20°C
• InChI: 1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H
• InChI key: KKLWSPPIRBIEOV-UHFFFAOYSA-N

Description

Application

Buformin hydrochloride has been used as an internal standard in liquid chromatography-tandem mass spectrometry to analyze postmortem distribution/redistribution of buformin in body fluids and solid tissues in an autopsy case.

Biochem/physiol Actions

Buformin is an oral antidiabetic drug with antiproliferative properties; AMPK activator. Buformin, an antidiabetic biguanide drug, was withdrawn as an antidiabetic drug in several countries because of the side effect of lactic acidosis, but is now being investigated as an anticancer agent. Buformin inhibits the growth and development of cancer. Buformin has been shown to postpone spontaneous carcinogenesis as well as inhibit induced carcinogenesis in animal studies. Buformin decreased cancer incidence, multiplicity, and burden in a rat study of chemically induced mammary carcinogenesis. Buformin also reduced renal cell carcinoma survival under conditions of glucose deprivation. Buformin′s anticancer activity is thought to involve disruption of the Warburg effect by AMPK activation, which decreases hepatic glucose production, and inhibition of the mTor pathway.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H318,H335
• Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable