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Key Documents

SML0783

Sigma-Aldrich

Sauchinone

≥98% (HPLC)

Synonym(s):

(5aα,7α,8β,8aβ,14aS*,14bβ)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one, (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one

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1 G
MXP 947.00
5 G
MXP 2,440.00
25 G
MXP 5,865.00

MXP 947.00


Availability

Estimated to ship onFebruary 23, 2025


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1 G
MXP 947.00
5 G
MXP 2,440.00
25 G
MXP 5,865.00

About This Item

Empirical Formula (Hill Notation):
C20H20O6
CAS Number:
Molecular Weight:
356.37
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

MXP 947.00


Availability

Estimated to ship onFebruary 23, 2025


Request a Bulk Order

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O=C(C=C1OCO2)[C@]3([H])C[C@@H](C)[C@H](C)[C@@]4([H])C5=CC6=C(OCO6)C=C5O[C@]12[C@]43[H]

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Show Differences

1 of 4

This Item
SML2610PHL83906SML0413
Seselin ≥98% (HPLC)

SML2610

Seselin

FQI1 ≥98% (HPLC)

SML0413

FQI1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 10 mg/mL (clear solution)

color

white to beige

color

white to beige

color

-

color

white to beige

Biochem/physiol Actions

Sauchinone is an anti-inflammatory and antioxidant lignan isolated from Saururus chinensis a medical plant used for the treatment of fever, jaundice, oedema and inflammatory disease in oriental folk medicine. Sauchinone inhibits LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IKBα phosphorylation. It appears that sauchinone protects against myocardial ischemia/reperfusion injury by inhibition of p28 phosphorylation.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Jung Joo Yoon et al.
International journal of molecular sciences, 21(19) (2020-09-27)
Abnormal and excessive growth of mesangial cells is important in the pathophysiologic processes of diabetes-associated interstitial fibrosis and glomerulosclerosis, leading to diabetic nephropathy, which eventually turns into end-stage renal disease. Sauchinone, a biologically-active lignan isolated from aerial parts of Saururus

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