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Key Documents

SAB5300177

Sigma-Aldrich

Anti-SOX2 Antibody

mouse monoclonal, 10F10

Synonym(s):

Sox-2, Sox2, lcc, ysb

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

product name

Monoclonal Anti-SOX2 antibody produced in mouse, clone 10F10, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

10F10, monoclonal

mol wt

34 kDa

species reactivity

human

technique(s)

direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000

isotype

IgG1

UniProt accession no.

P48431

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SOX2(20674)

General description

SOX2 (sex-determining region Y-box 2) is a transcription factor consisting of 317 amino acids. It has an HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.

Immunogen

Purified recombinant fragment of human SOX2 expressed in E.coli.
Mouse monoclonal antibody raised against SOX2

Application

Monoclonal Anti-SOX2 antibody has been used as a core pluripotency factor to regulate stem cell pluripotency.

Biochem/physiol Actions

SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maryam Alowaysi et al.
Stem cell research, 49, 102008-102008 (2020-09-29)
Klinefelter Syndrome (KS) is the most frequent X chromosome aneuploidy in males. KS patients with 47-XXY, 48-XXXY and 49-XXXXY karyotypes endure inter-individual phenotypic variabilities including infertility, cardiac diseases, metabolic and psychiatric disorders. We derived iPSC lines from a high-grade 49-XXXXY KS and
Maryam Alowaysi et al.
Stem cell research, 49, 102042-102042 (2020-10-18)
Klinefelter Syndrome (KS) is caused by the presence of a supernumerary X chromosome. Cytogenetic studies revaled that 80-90% of patients carry a 47-XXY karyotype, while 10-20% of cases are represented by mosaic 46-XY/47-XXY and high-grade aneuploidies 48-XXXY and 48-XXYY. The phenotypic traits
Maryam Alowaysi et al.
Stem cell research, 50, 102148-102148 (2021-01-10)
Glucagon-like peptide-1 receptor (GLP1R) is a seven-transmembrane-spanning helices membrane protein expressed in multiple human tissues including pancreatic islets, lung, brain, heart and central nervous system (CNS). GLP1R agonists are commonly used as antidiabetic drugs, but a neuroprotective function in neurodegenerative
Elisabetta Fiacco et al.
Stem cell research, 49, 102049-102049 (2020-10-24)
While Klinefelter Syndrome (KS) has a prevalence of 85-250 per 100,000 born males, patients are typically underdiagnosed due to a subtle phenotype emerging only late during puberty or adulthood. Rare cases of KS carry a mosaic phenotype 47-XXY/46-XY associated to
Maryam Alowaysi et al.
Stem cell research, 49, 102098-102098 (2020-12-01)
Klinefelter Syndrome (KS) is the most common aneuploidy in humans (prevalence: 85-250 per 100,000 born males) and is characterized by one or more supernumerary X-chromosomes (47-XXY, 48-XXXY and 49-XXXXY karyotypes). KS is a multisystemic disorder associated to multiple phenotypic features
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