SAB5200921

Monoclonal Anti-Notch1 - Percp antibody produced in mouse

clone S253-32, purified immunoglobulin

• Synonym(s): Anti-Motch, Anti-Neurogenic locus notch homolog protein 1, Anti-Neurogenic locus notch protein homolog, Anti-TAN1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: Peridinin-Chlorophyll-Protein Complex
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: S253-32, monoclonal
• form: buffered aqueous solution
• mol wt: antigen predicted mol wt >270, ~120 kDa
• species reactivity: mouse, rat, human
• concentration: 1 mg/mL
• technique(s): immunocytochemistry: suitable; western blot: suitable
• isotype: IgG1
• NCBI accession no.: NP_032740.3
• UniProt accession no.: Q07008
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Notch1(18128)

Description

General description

The NOTCH1 gene is mapped to human chromosome 9q34.3. In mice, Notch1 is highly expressed in immature neurons of hippocampus. Notch1 is localized to renal epithelial cells and podocytes of metanephros.

Immunogen

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1

Biochem/physiol Actions

The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Notch signaling pathway is involved in the development and progress of cardiovascular diseases. Notch1 function is predominant in developing kidney compared to compared to the mature organ.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable