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Key Documents

SAB4503272

Sigma-Aldrich

Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ICE, IL-1 β, IL-1 β converting enzyme, IL-1BC, caspase-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 25 kDa
antigen 45 kDa

species reactivity

human

concentration

~1 mg/mL

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This Item
PRS3463SAB4503316SAB4503294
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

species reactivity

human

species reactivity

human

species reactivity

human, mouse

species reactivity

human, mouse, rat

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

General description

Anti-CASP-1 (Cleaved-Asp210) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp210) protein.
Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human IL-1 beta.

Immunogen Range: 161-210

Biochem/physiol Actions

Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)).
Kumar Y, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2008)
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.
Shamaa OR, et al.
PLoS ONE, 10(11) (2015)
Overexpression of caspase-1 in aorta of patients with coronary atherosclerosis
Zheng F, et al.
Heart, Lung & Circulation, 23(11), 1070-1074 (2014)

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