Anti-SOX9 antibody detects endogenous levels of total SOX9 protein.
The SOX9 (SRY (sex determining region Y)-box 9) gene is located on human chromosome 17q24.3. SOX9 codes for a DNA-binding protein that belongs to the class of high-mobility-group box.
Immunogen
The antiserum was produced against synthesized peptide derived from human SOX9.
Immunogen Range: 147-196
Biochem/physiol Actions
The protein encoded by SOX9 (SRY (sex determining region Y)-box 9) gene is involved in the regulation of developmental processes such as chondrogenesis, gliogenesis, epithelial hair follicle stem cell specification, gonadogenesis, normal development of septum, lung, cardiac valve and pancreas. Abnormal regulation of SOX9 promotes tumorigenesis in different tissues. SOX9 induces the process of metastasis in cancer cells. Overexpression of the gene is observed in prostate, breast, and colorectal cancers.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.
Egunsola AT
The Journal of Clinical Investigation, 127(4), 1475-1484 (2017)
Expression and Clinical Significance of SOX9 in Renal Cell Carcinoma, Bladder Cancer and Penile Cancer.
Wan YP
Oncology research and treatment, 40(1-2), 15-20 (2017)
Position effects due to chromosome breakpoints that map approximately 900 Kb upstream and approximately 1.3 Mb downstream of SOX9 in two patients with campomelic dysplasia.
Velagaleti GV
American Journal of Human Genetics, 76(4), 652-662 (2005)
The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed a high level of
SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
Richtig G
PLoS ONE, 12(11), 1-15 (2017)
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