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Key Documents

PLA0105

Sigma-Aldrich

Rabbit anti-XRN1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

SEP1, strand-exchange protein 1 homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:5,000- 1:15,000

accession no.

Q6MZS8

UniProt accession no.

Q8IZH2

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... XRN1(54464)

Immunogen

The epitope recognized by PLA0105 maps to a region between residue 1650 and the C-terminus (residue 1706) of human 5′-3′ Exoribonuclease 1 using the numbering given in TrEMBL entry Q6MZS8 (GeneID 54464).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

5′-3′ exoribonuclease 1 (XRN1) is a ribonuclease localized in the cytoplasm that functions in mRNA metabolism and is found in messenger ribonucleoprotein (mRNP) complexes. The mouse and yeast homologs of XRN1 are Dhm2 and SEP1 respectively. In a glial cell line, XRN1 is induced by glial cell line–derived growth factor (GDNF) and associates with microtubules. XRN1 has also been identified as a candidate tumor suppressor gene in osteogenic sarcoma.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yang Luo et al.
Biochemistry, 59(43), 4176-4188 (2020-05-05)
Decapping is the first committed step in 5'-to-3' RNA decay, and in the cytoplasm of human cells, multiple decapping enzymes regulate the stabilities of distinct subsets of cellular transcripts. However, the complete set of RNAs regulated by any individual decapping
Zhenkun Na et al.
Biochemistry, 59(42), 4131-4142 (2020-10-17)
Proteogenomic identification of translated small open reading frames in humans has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been shown to be essential for cell
Jonathan C Reed et al.
Journal of virology, 95(3) (2020-11-06)
Given the projected increase in multidrug-resistant HIV-1, there is an urgent need for development of antiretrovirals that act on virus life cycle stages not targeted by drugs currently in use. Host-targeting compounds are of particular interest because they can offer

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