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L9634

Sigma-Aldrich

Laminarin from Laminaria digitata

polysaccharide substrate for laminarinase

Synonym(s):

Laminaran

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About This Item

CAS Number:
9008-22-4
EC Number:
232-712-4
MDL number:
MFCD00466918
UNSPSC Code:
12352201
PubChem Substance ID:
329817672
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

algae (Laminaria digitata)

Quality Level

200

form

powder

optical activity

[α]20/D -20 to -5 °, c = 4% (w/v) in water

color

beige

useful pH range

5

solubility

water: 10 mg/mL, clear to slightly hazy, colorless to light yellow

storage temp.

room temp

SMILES string

O1[C@@H]([C@H]([C@@H]([C@H](C1O[C@H]3[C@@H]([C@H](OC([C@@H]3O)O)CO)O)O)OC2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)O)CO

InChI

1S/C18H32O16/c19-1-4-7(22)10(25)11(26)17(31-4)34-15-9(24)6(3-21)32-18(13(15)28)33-14-8(23)5(2-20)30-16(29)12(14)27/h4-29H,1-3H2/t4-,5-,6-,7-,8-,9-,10+,11-,12-,13-,14+,15+,16?,17?,18?/m1/s1

InChI key

DBTMGCOVALSLOR-VPNXCSTESA-N

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General description

The fronds of Laminaria and Saccharina species contain laminarin, a low molecular weight[1] storage glucan. It is localized to the vacuoles.[2] Laminarin structure contains β-(1,6)-intrachain linked (1,3)-β-d-glucan.[1]

Application

Laminarin from Laminaria digitata has been used:
  • as a stimulant to study its effect on the respiratory burst using haemocytes of P. vannamei[3]
  • as a carbon source to study its effect on enzyme production using Pichia membranifaciens culture[4]
  • as a carbon source for Polaribacter sp. culture[5]

Biochem/physiol Actions

Laminarin is a biologically active compound effective against inflammation. It serves as an antioxidant and anticoagulant. Laminarin also inhibits apoptosis and tumor development.[1] It acts as a predominant source of carbon among aquatic prokaryotes.[2]
Laminarin is a polysaccharide of glucose found in brown algae and utilized as a food reserve.

Other Notes

Polysaccharide; primarily poly(β-Glc-[1→3]) with some β-(1→6) interstrand linkages and branch points.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Substrates

Substrate for laminarinase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000431164
0000431164
0000426935
0000426934
0000426933

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Measurement of reactive oxygen intermediate production in haemocytes of the penaeid shrimp, Penaeus vannamei
Munoz M, et al.
Aquaculture (Amsterdam, Netherlands), 191(1-3), 89-107 (2000)
Ji Hyeon Ahn et al.
Marine drugs, 18(7) (2020-07-08)
A number of studies have demonstrated that marine carbohydrates display anti-oxidant, anti-melanogenic, and anti-aging activities in the skin. Laminarin (LA), a low-molecular-weight polysaccharide, is found in brown algae. The benefits of LA in ultraviolet B (UVB) induced photodamage of the
Extraction, structure and biofunctional activities of laminarin from brown algae
Kadam SU, et al.
International Journal of Food Science and Technology, 50(1), 24-31 (2015)
Characterization of marine bacteria and the activity of their enzyme systems involved in degradation of the algal storage glucan laminarin
Alderkamp AC, et al.
FEMS Microbiology Ecology, 59(1), 108-117 (2006)
Choa An et al.
Applied and environmental microbiology, 79(3), 860-866 (2012-11-28)
Edible brown algae are used as major food material in Far East Asian countries, particularly in South Korea and Japan. They contain fermentable dietary fibers, alginic acid (uronic acid polymer) and laminaran (β-1,3-glucan), that are fermented into organic acids by
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Questions

1–9 of 9 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. ラミナリンはLPSフリーでしょうか？

    1 answer

    1. This product is isolated from the algae Laminaria digitata. LPS (Lipopolypolysaccharide) is a product of bacteria. During processing, the material is not intentionally exposed to bacteria. The expectation is that this item would have a very low LPS content. However, the product is not tested for the presence of LPS and is not guaranteed to be LPS-free.

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  4. Could you kindly provide the molecular weight of L9634?

    1 answer

    1. The determination of the molecular weight has not been conducted. However, based on archived data, the reported molecular weight for one of the lots is 8,600. We recommend validating this data on your end as we have not conducted specific testing for it.

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  5. Laminarin is considered a neutral polysaccharide. However, at interaction studies with a quartz crystal microbalance and the bound to particles it omitted a negative charge. Is it possible that Laminarin contains negativley charged groups?

    1 answer

    1. The charge state of this product has not been investigated. There are publications available which claim that it is neutral, however the link below is reporting laminarin as negatively charged. Unfortunately, no further information is available.
      https://www.sciencedirect.com/science/article/abs/pii/S0013935123007016

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  6. Pourriez-vous m'indiquer le degré de pureté du produit. Je ne l'ai pas trouvé. Merci

    1 answer

    1. Purity is not reported as a specification for this product.

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  7. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  8. What is the exact molecular weight (MW) of Product L9634, Laminarin?

    1 answer

    1. Product L9634, Laminarin, is a mixture of different carbohydrates of different MW values.  One publication has done a detailed ESI-MS analysis of laminarin from Laminaria digitata.  Read, S.M., et al., Analysis of the structural heterogeneity of laminarin by electrospray-ionisation-mass spectrometry.  Carbohydrate Res., 281(2), 187-201 (1996).

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  9. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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