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G1149

Sigma-Aldrich

L-Glutamic acid potassium salt monohydrate

BioReagent, suitable for insect cell culture, ≥99% (HPLC)

Synonym(s):

(S)-2-Aminopentanedioic acid, L-α-Aminoglutaric acid potassium salt, L-2-Aminopentanedioic acid potassium salt, Glu, Potassium L-glutamate

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About This Item

Empirical Formula (Hill Notation):
C5H8KNO4 · H2O
CAS Number:
6382-01-0
Molecular Weight:
203.23
Beilstein:
3637377
MDL number:
MFCD00150343
UNSPSC Code:
12352209
PubChem Substance ID:
24895045
NACRES:
NA.75

product line

BioReagent

Quality Level

200

Assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | insect: suitable

color

white

SMILES string

O.[K+].N[C@@H](CCC([O-])=O)C(O)=O

InChI

1S/C5H9NO4.K.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1

InChI key

XIBUKSQTWSKJMQ-QTNFYWBSSA-M

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General description

L-Glutamic acid, an amino acid is mainly found in various food products in its free form. It is ubiquitously present in the brain of mammals.

Application

L-Glutamic acid potassium salt monohydrate has been used as a component in KG buffer for cardiomyocyte isolation and culture.

Biochem/physiol Actions

L-Glutamic acid plays a major role in several metabolic pathways. It acts as excitatory neurotransmitter in the cerebral cortex. An plays a key role in learning, memory and brain aging processes. It is involved in neuronal differentiation, migration and survival in the developing brain. High levels of glutamic acid is observed in Alzheimer′s, Parkinson′s diseases and epilepsy.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The HCM-linked W792R mutation in cardiac myosin-binding protein C reduces C6 FnIII domain stability
Smelter DF, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 314(6), H1179-H1191 (2018)
Stability and solution structure of binary and ternary Cu (II) complexes with l-glutamic acid and diamines as well as adducts in metal-free systems in aqueous solution
Bregier-JR
Journal of Solution Chemistry, 43(12), 2144-2162 (2014)
Robbin Schnieders et al.
Current protocols in nucleic acid chemistry, 82(1), e116-e116 (2020-09-23)
NMR spectroscopy is a potent method for the structural and biophysical characterization of RNAs. The application of NMR spectroscopy is restricted in RNA size and most often requires isotope-labeled or even selectively labeled RNAs. Additionally, new NMR pulse sequences, such
William Krogman et al.
International journal of molecular sciences, 21(17) (2020-09-06)
Cytoplasmic calcium ([Ca2+]cyt) is a well-characterized second messenger in eukaryotic cells. An elevation in [Ca2+]cyt levels is one of the earliest responses in plant cells after exposure to a range of environmental stimuli. Advances in understanding the role of [Ca2+]cyt
Oksana Forostyak et al.
Stem cells and development, 22(10), 1506-1521 (2013-01-09)
Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+) ion is an important intracellular messenger essential for the regulation of various
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