Skip to Content
Merck
All Photos(2)

Key Documents

F5006

Sigma-Aldrich

2-Fluoro-2-deoxy-D-glucose

glycosylation inhibitor, glucose analog

Synonym(s):

2-Deoxy-2-fluoro-D-glucose, FDG, 2-Deoxy-2-fluoro-D-glucose

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C6H11FO5
CAS Number:
Molecular Weight:
182.15
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.32

Pricing and availability is not currently available.

Quality Level

storage temp.

2-8°C

SMILES string

OCC1OC(O)C(F)C(O)C1O

InChI

1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2

InChI key

ZCXUVYAZINUVJD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
GF39961862GF29339286GF85865181
form

wire

form

wire

form

wire

form

wire

assay

≥99.99%

assay

99.95%

assay

99.90%

assay

≥99.9%

density

21.45 g/cm3 (lit.)

density

21.45 g/cm3 (lit.)

density

21.45 g/cm3 (lit.)

density

21.45 g/cm3 (lit.)

bp

3827 °C (lit.)

bp

3827 °C (lit.)

bp

3827 °C (lit.)

bp

3827 °C (lit.)

resistivity

10.6 μΩ-cm, 20°C

resistivity

10.6 μΩ-cm, 20°C

resistivity

10.6 μΩ-cm, 20°C

resistivity

10.6 μΩ-cm, 20°C

General description

2-Fluoro-2-deoxy-D-glucose is non-toxic and a structural analog of glucose, significantly inhibiting glycosylation. As a glucose analog, uptake of 2-Fluoro-2-deoxy-D-glucose is rapid in brain and heart cells.[1]

2-Fluoro-2-deoxy-D-glucose can be taken up by cells but does not undergo metabolic glycolysis.

Application

2-Fluoro-2-deoxy-D-glucose is used as a tracer for rapid tumor detection.[1] It is used as a glucose analog to study glucose uptake in mice with radiation and burn injuries. [2]Oncology therapy studies use FDG in combination with PET (Positron Emission Topography)

Biochem/physiol Actions

Glucose analog that inhibits cellular glycosylation.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

  • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Need A Sample COA?

    This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    C J Hoekstra et al.
    European journal of nuclear medicine, 27(6), 731-743 (2000-07-20)
    [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) is considered a valuable tool in the diagnosis and staging of cancer. In addition, it seems promising as a technique to monitor response to therapy. Progress is hampered, however, by the fact that various
    G J Bosman et al.
    Biochimica et biophysica acta, 696(3), 285-289 (1982-03-29)
    Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells
    Frank J Brooks et al.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 37-42 (2013-11-23)
    The number of studies in the literature involving quantification of the metabolic heterogeneity seen in (18)F-FDG PET images has increased sharply over recent years. We hypothesized that inclusion of very small regions of interest as unique data points will have
    Sandy R Shultz et al.
    Epilepsia, 54(7), 1240-1250 (2013-05-31)
    Posttraumatic epilepsy (PTE) occurs in a proportion of traumatic brain injury (TBI) cases, significantly compounding the disability, and risk of injury and death for sufferers. To date, predictive biomarkers for PTE have not been identified. This study used the lateral
    Maarten J Vosselman et al.
    The American journal of clinical nutrition, 98(1), 57-64 (2013-05-31)
    Studies in rodents have shown that brown adipose tissue (BAT) is activated on food intake, thereby reducing metabolic efficiency. The current study investigated whether a single high-calorie, carbohydrate-rich meal activates BAT in lean human adults. BAT activity was studied in

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service