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B4153

Sigma-Aldrich

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride

~95%

Synonym(s):

Boc-Gln-Ala-Arg-AMC hydrochloride, Boc-Gln-Ala-Arg-Mca hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C29H42N8O8 · HCl
CAS Number:
113866-20-9
Molecular Weight:
667.15
MDL number:
MFCD00080216
UNSPSC Code:
12352204
PubChem Substance ID:
24891756
NACRES:
NA.32

Assay

~95%

Quality Level

200

form

powder

solubility

methanol: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(NC(=O)C(CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C29H42N8O8/c1-15-13-23(39)44-21-14-17(8-9-18(15)21)35-26(42)19(7-6-12-33-27(31)32)36-24(40)16(2)34-25(41)20(10-11-22(30)38)37-28(43)45-29(3,4)5/h8-9,13-14,16,19-20H,6-7,10-12H2,1-5H3,(H2,30,38)(H,34,41)(H,35,42)(H,36,40)(H,37,43)(H4,31,32,33)

InChI key

LQSLBVXESNRILG-UHFFFAOYSA-N

General description

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride is a fluorogenic and cell-permeable trypsin substrate.

Application

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride has been used as a fluorogenic substrate to measure the enzymatic activity of trypsin.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

Substrate for trypsin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Evaluation of fluorogenic substrates in the assessment of digestive enzymes in a decapod crustacean Maja brachydactyla larvae
Rotllant G, et al.
Aquaculture (Amsterdam, Netherlands), 282(1-4), 90-96 (2008)
Diel food intake and digestive enzyme production patterns in Solea senegalensis larvae
Navarro-Guillen C, et al.
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Morphological and physiological changes of Octopus bimaculoides: from embryo to juvenile
Ibarra-Garcia LE, et al.
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Digestive biochemistry as indicator of the nutritional status during early development of the long snouted seahorse (Hippocampus reidi)
Novelli B, et al.
Aquaculture (Amsterdam, Netherlands), 464, 196-204 (2016)
Dodheri Syed Samiulla et al.
Organic and medicinal chemistry letters, 2(1), 27-27 (2012-07-17)
Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of inhibitors. To date, only a few series of non-peptide inhibitors
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