Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

T63002

Sigma-Aldrich

2,2,2-Trifluoroethanol

ReagentPlus®, ≥99%

Synonym(s):

Trifluoroethyl alcohol

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
CF3CH2OH
CAS Number:
75-89-8
Molecular Weight:
100.04
Beilstein:
1733203
EC Number:
200-913-6
MDL number:
MFCD00004672
UNSPSC Code:
12191601
PubChem Substance ID:
329826635
NACRES:
NA.21

vapor density

3.5 (vs air)

vapor pressure

70 mmHg ( 25 °C)

product line

ReagentPlus®

Assay

≥99%

form

liquid

autoignition temp.

~896 °F

expl. lim.

42 %

refractive index

n20/D 1.3 (lit.)

pH

7

bp

77-80 °C (lit.)

mp

−44 °C (lit.)

density

1.373 g/mL at 25 °C (lit.)

SMILES string

OCC(F)(F)F

InChI

1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

InChI key

RHQDFWAXVIIEBN-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

2,2,2-Trifluoroethanol (TFE) is an organic compound with the chemical formula CF3CH2OH. TFE is a commonly used solvent in organic synthesis. It can also be used as a cosolvent in the experimental study of proteins and peptides.

Application

2,2,2-Trifluoroethanol can be used as a solvent:
  • In the synthesis of 2-amino-3-cyano-4H-chromene and tetrahydrobenzo[b]pyran derivatives by catalyst free one-pot condensation of aldehydes, malononitrile and resorcinol or dimedone.
  • In the N-formylation of amines with formic acid in the presence of heterogeneous ZIF-8 (zeolitic imidazolate framework) catalyst.
  • In the preparation of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by condensation of anthranilamide with alkyl, aryl, or heteroaryl ketones or aldehydes.
  • In the mild and selective oxidation of sulfur compounds using H2O2(hydrogen peroxide).

Features and Benefits

2,2,2-Trifluoroethanol is more acidic than ethanol due to the presence of electronegative trifluoromethyl group.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - STOT RE 2 Inhalation

Target Organs

Blood

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

86.0 °F - closed cup

Flash Point(C)

30 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

2,2,2-Trifluoroethanethiol 95%

Sigma-Aldrich

374008

2,2,2-Trifluoroethanethiol

2,2,2-Trichloroethanol ReagentPlus®, ≥99%

Sigma-Aldrich

T54801

2,2,2-Trichloroethanol

Hannah A Strobel et al.
Tissue engineering. Part A, 24(19-20), 1492-1503 (2018-05-05)
Tissue-engineered human blood vessels may enable in vitro disease modeling and drug screening to accelerate advances in vascular medicine. Existing methods for tissue-engineered blood vessel (TEBV) fabrication create homogenous tubes not conducive to modeling the focal pathologies characteristic of certain
Jie E Yang et al.
Scientific reports, 10(1), 7939-7939 (2020-05-16)
Enteroviruses support cell-to-cell viral transmission prior to their canonical lytic spread of virus. Poliovirus (PV), a prototype for human pathogenic positive-sense RNA enteroviruses, and picornaviruses in general, transport multiple virions en bloc via infectious extracellular vesicles, 100~1000 nm in diameter, secreted
Deborah Chang et al.
Molecular & cellular proteomics : MCP, 19(9), 1533-1545 (2020-07-01)
Influenza A virus (IAV) mutates rapidly, resulting in antigenic drift and poor year-to-year vaccine effectiveness. One challenge in designing effective vaccines is that genetic mutations frequently cause amino acid variations in IAV envelope protein hemagglutinin (HA) that create new N-glycosylation
Erin K Zess et al.
PLoS biology, 17(7), e3000373-e3000373 (2019-07-23)
Autophagy-related protein 8 (ATG8) is a highly conserved ubiquitin-like protein that modulates autophagy pathways by binding autophagic membranes and a number of proteins, including cargo receptors and core autophagy components. Throughout plant evolution, ATG8 has expanded from a single protein
Bei Feng et al.
Biomacromolecules, 13(12), 3917-3925 (2012-11-08)
In tissue engineering research, there has recently been considerable interest in using electrospun biomimetic nanofibers of hybrids, in particular, from natural and synthetic polymers for engineering different tissues. However, phase separation between a pair of much dissimilar polymers might give
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service