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A1250000

Aprotinin solution

BRP, European Pharmacopoeia (EP) Reference Standard

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About This Item

CAS Number:
UNSPSC Code:
41116107
NACRES:
NA.24

Pricing and availability is not currently available.

biological source

bovine

grade

pharmaceutical primary standard

API family

aprotinin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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This Item
Y0001154A1153A6279
manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

format

neat

format

neat

format

-

format

-

biological source

bovine

biological source

-

biological source

bovine lung

biological source

bovine

API family

aprotinin

API family

aprotinin

API family

-

API family

-

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aprotinin solution EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Regulatory decisions pertaining to aprotinin may be putting patients at risk.
    Paul C Hébert et al.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 186(18), 1379-1386 (2014-10-01)
    D Royston
    Anaesthesia, 70 Suppl 1, 46-49 (2014-12-03)
    There is a considerable difference between the mechanism of action of the lysine analogues, tranexamic acid and epsilon-aminocaproic acid, and the serine protease inhibitor aprotinin. Aprotinin acts to inactivate free plasmin, but with little effect on bound plasmin, whereas the
    Ulrich Weininger et al.
    Biochemistry, 53(28), 4519-4525 (2014-07-02)
    Intramolecular motions of proteins are critical for biological function. Transient structural fluctuations underlie a wide range of processes, including enzyme catalysis, ligand binding to buried sites, and generic protein motions, such as 180° rotation of aromatic side chains in the
    Philippe Leroux et al.
    Journal of neuropathology and experimental neurology, 73(5), 387-402 (2014-04-09)
    Intracerebral-intraventricular hemorrhages (ICH/IVH) in very preterm neonates are responsible for high mortality and subsequent disabilities. In humans, tissue plasminogen activator (t-PA) initiates fibrinolysis and activates endoluminal-endothelial receptors; dysfunction of the t-PA inhibitor (PAI-1) results in recurrent hemorrhages. We used PAI-1
    Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.
    Aimee M Two et al.
    The Journal of investigative dermatology, 134(4), 1143-1145 (2013-11-12)

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